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Article

Discovery and engineered overproduction of antimicrobial nucleoside antibiotic A201A from the deep-sea marine actinomycete Marinactinospora thermotolerans SCSIO 00652.

Antimicrobial agents and chemotherapy - 1 Jan 2012

Zhu Qinghua, Li Jun, Ma Junying, Luo Minghe, Wang Bo, Huang Hongbo, Tian Xinpeng, Li Wenjun, Zhang Si, Zhang Changsheng, Ju Jianhua

Abstract excerpt

Marinactinospora thermotolerans SCSIO 00652, originating from a deep-sea marine sediment of the South China Sea, was discovered to produce antimicrobial nucleoside antibiotic A201A. Whole-genome scanning and annotation strategies enabled us to localize the genes responsible for A201A biosynthesis and to experimentally identify the gene cluster; inactivation of mtdF, an oxidoreductase gene within the suspected...

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PMID: 22064543
DOI: 10.1128/AAC.05278-11
PMCID: PMC3256081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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