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Article

Characterization of tiacumicin B biosynthetic gene cluster affording diversified tiacumicin analogues and revealing a tailoring dihalogenase.

Journal of the American Chemical Society - 2 Feb 2011

Xiao Yi, Li Sumei, Niu Siwen, Ma Liang, Zhang Guangtao, Zhang Haibo, Zhang Gaiyun, Ju Jianhua, Zhang Changsheng

Abstract excerpt

The RNA polymerase inhibitor tiacumicin B is currently undergoing phase III clinical trial for treatment of Clostridium difficile associated diarrhea with great promise. To understand the biosynthetic logic and to lay a foundation for generating structural analogues via pathway engineering, the tiacumicin B biosynthetic gene cluster was identified and characterized from the producer Dactylosporangium aurantiacum...

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PMID: 21186805
DOI: 10.1021/ja109445q

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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