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Article

Avirulence of Candida albicans CaHK1 mutants in a murine model of hematogenously disseminated candidiasis.

Infection and immunity - 1 Aug 1999

Calera J A, Zhao X J, De Bernardis F, Sheridan M, Calderone R

Abstract excerpt

Deletion of both alleles of the Candida albicans CaHK1 gene, which causes cells to flocculate when grown at pH 7.5, a pH comparable to that of mammalian blood, abolishes the ability of the yeast to establish a successful infection in a murine model of hematogenously disseminated candidiasis. Within 72 h all mice inoculated with the parental C. albicans strain had died. The mice infected with either the...

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Identifiers

PMID: 10417206
DOI: 10.1128/IAI.67.8.4280-4284.1999
PMCID: PMC96739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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