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Article

Asthma-related SNP in FCER2 is associated with increased expression of IL-4R on human B cells.

International journal of immunogenetics - 1 Dec 2011

Chan M A, Gigliotti N M, Meng J, Rosenwasser L J

Abstract excerpt

A SNP (rs2228137) (R62W) in FCER2 has been linked with severe exacerbations in asthmatics. Transfectants expressing the SNP exhibited increased IL-4Rα expression after stimulation through CD23 compared with wild-type. Our data suggest that the SNP may favour increased IgE production through increased responsiveness to IL-4 in patients possessing this genotype.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Interleukin-4 Receptor alpha Subunit

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Source

Identifiers

PMID: 22059556
DOI: 10.1111/j.1744-313X.2011.01043.x

Genes

FCER2

Variants

rs2228137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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