Article
CHEK2*1100delC homozygosity is associated with a high breast cancer risk in women.
Journal of medical genetics - 1 Dec 2011
Adank Muriel A, Jonker Marianne A, Kluijt Irma, van Mil Saskia E, Oldenburg Rogier A, Mooi Wolter J, Hogervorst Frans B L, van den Ouweland Ans M W, Gille Johan J P, Schmidt Marjanka K, van der Vaart Aad W, Meijers-Heijboer Hanne, Waisfisz Quinten
Abstract excerpt
BACKGROUND: Mutations in the CHEK2 gene confer a moderately increased breast cancer risk. The risk for female carriers of the CHEK2*1100delC mutation is twofold increased. Breast cancer risk for carrier women is higher in a familial breast cancer setting which is due to coinheritance of additional genetic risk factors. This study investigated the occurrence of homozygosity for the CHEK2*1100delC allele among...
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