Article
Relation of lipid gene scores to longitudinal trends in lipid levels and incidence of abnormal lipid levels among individuals of European ancestry: the Atherosclerosis Risk in Communities (ARIC) study.
Circulation. Cardiovascular genetics - 1 Feb 2012
Lutsey Pamela L, Rasmussen-Torvik Laura J, Pankow James S, Alonso Alvaro, Smolenski Derek J, Tang Weihong, Coresh Josef, Volcik Kelly A, Ballantyne Christie M, Boerwinkle Eric, Folsom Aaron R
Abstract excerpt
BACKGROUND: Multiple genetic loci have been associated with blood lipid levels. We tested the hypothesis that persons with an unfavorable lipid gene profile would experience a greater increase in lipid levels and a higher incidence of abnormal lipid levels relative to those with more-favorable lipid gene profiles. METHODS AND RESULTS: A total of 9328 individuals of European descent (aged 45-64 years) in the ARIC...
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