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Insights from population-based analyses of plasma lipids across the allele frequency spectrum.

Current opinion in genetics & development - 1 Jun 2018

Peloso Gina M, Natarajan Pradeep

Abstract excerpt

Plasma lipid levels are heritable quantitative risk factors and therapeutic targets for cardiovascular disease. Plasma lipids have been a model for translating genetic observations across the allele frequency spectrum to unique biological and therapeutic insights. Most large studies to date predominately comprised of individuals of European ancestry. This review focuses on contemporary evidence from 2016 to 2017...

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Gene Frequency
Genetics, Population
Genome-Wide Association Study
Lipid Metabolism

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Quantitative Trait Loci

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PMID: 29448166
DOI: 10.1016/j.gde.2018.01.003
PMCID: PMC6087690

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