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Article

Loss of zebrafish lgi1b leads to hydrocephalus and sensitization to pentylenetetrazol induced seizure-like behavior.

PloS one - 1 Jan 2011

Teng Yong, Xie Xiayang, Walker Steven, Saxena Meera, Kozlowski David J, Mumm Jeff S, Cowell John K

Abstract excerpt

Mutations in the LGI1 gene predispose to a hereditary epilepsy syndrome and is the first gene associated with this disease which does not encode an ion channel protein. In zebrafish, there are two paralogs of the LGI1 gene, lgi1a and lgi1b. Knockdown of lgi1a results in a seizure-like hyperactivity phenotype with associated developmental abnormalities characterized by cellular loss in the eyes and brain. We have...

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Source

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Identifiers

PMID: 22053218
DOI: 10.1371/journal.pone.0024596
PMCID: PMC3203530

Genes

LGI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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