Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of a Tryptophan 6-Halogenase from Streptomyces albus and Its Regioselectivity Determinants.

Chembiochem : a European journal of chemical biology - 15 May 2020

Lee Jeongchan, Kim Joonwon, Kim Hyun, Kim Eun-Jung, Jeong Hee-Jin, Choi Kwon-Young, Kim Byung-Gee

Abstract excerpt

Tryptophan halogenases are found in diverse organisms and catalyze regiospecific halogenation. They play an important role in the biosynthesis of halogenated indole alkaloids, which are biologically active and of therapeutic importance. Here, a tryptophan 6-halogenase (SatH) from Streptomyces albus was characterized by using a whole-cell reaction system in Escherichia coli. SatH showed substrate specificity for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutagenesis, Site-Directed

Share to Oxidoreductases

Share to Sequence Homology

Share to Streptomyces

Share to Substrate Specificity

Share to Tryptophan

Source

Identifiers

PMID: 31916339
DOI: 10.1002/cbic.201900723

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of a Tryptophan 6-Halogenase from Streptomyces albus and Its Regioselectivity Determinants.PMID 31916339Read ↗

A regioselective tryptophan 5-halogenase is involved in pyrroindomycin biosynthesis in Streptomyces rugosporus LL-42D005.Semantic proximity Read ↗

Continuous evolution of a halogenase enzyme with improved solubility and activity for sustainable bioproduction.Semantic proximity Read ↗

An Engineered Tryptophan Synthase Opens New Enzymatic Pathways to β-Methyltryptophan and Derivatives.Semantic proximity Read ↗

Enhancement of L-tryptophan 5-hydroxylation activity by structure-based modification of L-phenylalanine 4-hydroxylase from Chromobacterium violaceum.Semantic proximity Read ↗

Engineered Biosynthesis of β-Alkyl Tryptophan Analogues.Semantic proximity Read ↗

Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciensSemantic proximity Read ↗

Reengineering a tryptophan halogenase to preferentially chlorinate a direct alkaloid precursor.Semantic proximity Read ↗

New insights into the mechanism of enzymatic chlorination of tryptophan.Semantic proximity Read ↗

The Important Role of Halogen Bond in Substrate Selectivity of Enzymatic Catalysis.Semantic proximity Read ↗

Improving the activity of cytochrome P450 BM-3 catalyzing indole hydroxylation by directed evolution.Semantic proximity Read ↗

Aminomutases: mechanistic diversity, biotechnological applications and future perspectives.Semantic proximity Read ↗

Significant enhancement of the thermal stability and catalytic efficiency of transglutaminase in Streptomyces mobaraensis engineered through the novel S. mobaraensis genomic mutant library construction method GHR/Sml.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.