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Article

Discovery of novel androgen receptor antagonists: a hybrid approach of pharmacophore-based and docking-based virtual screening.

Anti-cancer drugs - 1 Aug 2015

Liu Jianzhen, Liu Bo, Guo Guangzhu, Jing Yongkui, Zhao Guisen

Abstract excerpt

Androgen receptor (AR) is an attractive target for the treatment of prostate cancer. An integrated pharmacophore-based and docking-based virtual screening approach was applied to identify novel AR antagonists with a distinct scaffold. The candidate compounds were evaluated for their abilities to inhibit prostate cancer cell proliferation and AR target gene prostate-specific antigen gene expression as well as the...

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Share to Androgen Receptor Antagonists
Share to Drug Screening Assays, Antitumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25933245
DOI: 10.1097/CAD.0000000000000245

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