Article
Positive association of the hepatic lipase gene polymorphism c.514C > T with estrogen replacement therapy response.
Lipids in health and disease - 2 Nov 2011
Pulchinelli Alvaro, Costa Ana Maria Massad, de Carvalho Cristina V, de Souza Naiara Correa Nogueira, Haidar Mauro A, Andriolo Adagmar, da Silva Ismael D C Guerreiro
Abstract excerpt
BACKGROUND: Hepatic lipase (HL), an enzyme present in the hepatic sinusoids, is responsible for the lipolysis of lipoproteins. Human HL contains four polymorphic sites: G-250A, T-710C, A-763G, and C-514T single-nucleotide polymorphism (SNPs). The last polymorphism is the focus of the current study. The genotypes associated with the C-514T polymorphism are CC (normal homozygous - W), CT (heterozygous - H), and TT...
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