Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The diversity of sex steroid action: novel functions of hydroxysteroid (17β) dehydrogenases as revealed by genetically modified mouse models.

The Journal of endocrinology - 1 Jan 2012

Saloniemi Taija, Jokela Heli, Strauss Leena, Pakarinen Pirjo, Poutanen Matti

Abstract excerpt

Disturbed action of sex steroid hormones, i.e. androgens and estrogens, is involved in the pathogenesis of various severe diseases in humans. Interestingly, recent studies have provided data further supporting the hypothesis that the circulating hormone concentrations do not explain all physiological and pathological processes observed in hormone-dependent tissues, while the intratissue sex steroid concentrations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 17-Hydroxysteroid Dehydrogenases
Share to Gonadal Steroid Hormones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hormonal Regulation and Hypertension

Share to Metabolic Networks and Pathways

Share to Mice, Transgenic

Share to Models, Animal

Share to Phenotype

Source

Identifiers

PMID: 22045753
DOI: 10.1530/JOE-11-0315

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The diversity of sex steroid action: novel functions of hydroxysteroid (17β) dehydrogenases as revealed by genetically modified mouse models.PMID 22045753Read ↗

Design and validation of specific inhibitors of 17 -hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosisSemantic proximity Read ↗

17β-Hydroxysteroid Dehydrogenases: Physiological Roles in Health and DiseaseSemantic proximity Read ↗

Perspectives in understanding the role of human 17beta-hydroxysteroid dehydrogenases in health and disease.Semantic proximity Read ↗

Differential androgen and estrogen substrates specificity in the mouse and primates type 12 17β-hydroxysteroid dehydrogenaseSemantic proximity Read ↗

Physiology and molecular genetics of 17 beta-hydroxysteroid dehydrogenases.Semantic proximity Read ↗

46,XX DSD due to Androgen Excess in Monogenic Disorders of Steroidogenesis: Genetic, Biochemical, and Clinical FeaturesSemantic proximity Read ↗

Current knowledge of the multifunctional 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1).Semantic proximity Read ↗

Hydroxysteroid (17{beta}) dehydrogenase 12 is essential for mouse organogenesis and embryonic survival.Semantic proximity Read ↗

Friend or enemy? Review of 17β-HSD10 and its role in human health or disease.Semantic proximity Read ↗

New Insights into Testosterone Biosynthesis: Novel Observations from HSD17B3 Deficient Mice.Semantic proximity Read ↗

The Biology of Human Sex DifferencesSemantic proximity Read ↗

Molecular Biology of the 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase Gene FamilySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.