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Hydroxysteroid (17{beta}) dehydrogenase 12 is essential for mouse organogenesis and embryonic survival.

Endocrinology - 1 Apr 2010

Rantakari Pia, Lagerbohm Heidi, Kaimainen Mika, Suomela Jukka-Pekka, Strauss Leena, Sainio Kirsi, Pakarinen Pirjo, Poutanen Matti

Abstract excerpt

Hydroxysteroid (17beta) dehydrogenases (HSD17Bs) have a significant role in steroid metabolism by catalyzing the conversion between 17-keto and 17beta-hydroxysteroids. However, several studies in vitro have shown that some of these enzymes may also be involved in other metabolic pathways. Among these enzymes, HSD17B12 has been shown to be involved in both the biosynthesis of estradiol and the elongation of the...

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Identifiers

PMID: 20130115
DOI: 10.1210/en.2009-0929

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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