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Article

Perspectives in understanding the role of human 17beta-hydroxysteroid dehydrogenases in health and disease.

Annals of the New York Academy of Sciences - 1 Feb 2009

Meier Marc, Möller Gabriele, Adamski Jerzy

Abstract excerpt

Steroid signaling involves specific receptors that mediate genomic effects and many further proteins responsible for fast nongenomic activities. Metabolism at the position 17 of the steroid scaffold plays a pivotal role in the final regulation of the biological potency of steroid hormones. Enzymes responsible for that, the 17beta-hydroxysteroid dehydrogenases (17beta-HSD), act as carbonyl reductases and require...

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PMID: 19250188
DOI: 10.1111/j.1749-6632.2009.03702.x

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