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Differential androgen and estrogen substrates specificity in the mouse and primates type 12 17β-hydroxysteroid dehydrogenase

19 Jul 2007

Abstract excerpt

Recently, we have shown that human and monkey type 12 17beta-hydroxysteroid dehydrogenases (17beta-HSD12) are estrogen-specific enzymes catalyzing the transformation of estrone (E(1)) into estradiol (E(2)). To further characterize this novel steroidogenic enzyme in an animal model, we have isolated a cDNA fragment encoding mouse 17beta-HSD12 and characterized its enzymatic activity. Using human embryonic kidney...

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PMID: 17641292
DOI: 10.1677/joe-07-0144

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