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Article

Corticotropin-Releasing Factor Receptor-1 Antagonism Reduces Oxidative Damage in an Alzheimer’s Disease Transgenic Mouse Model.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Zhang Cheng, Kuo Ching-Chang, Moghadam Setareh H, Monte Louise, Rice Kenner C, Rissman Robert A

Abstract excerpt

Reports from Alzheimer’s disease (AD) biomarker work have shown a strong link between oxidative stress and AD neuropathology. The nonenzymatic antioxidant, glutathione (GSH), plays a crucial role in defense against reactive oxygen species and maintenance of GSH redox homeostasis. In particular, our previous studies on GSH redox imbalance have implicated oxidative stress induced by excessive reactive oxygen...

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Source

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Identifiers

PMID: 25649650
DOI: 10.3233/JAD-141722
PMCID: PMC4486520

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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