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Article

p53 Arg72Pro polymorphism, adiposity status, and cancer risk: Two case-cohorts within a Japanese prospective study.

Cancer science - 1 Dec 2022

Nakano Shiori, Yamaji Taiki, Katagiri Ryoko, Sawada Norie, Inoue Manami, Tsugane Shoichiro, Iwasaki Motoki

Abstract excerpt

The tumor suppressor protein, p53, is a critical molecule involved in cancer development. However, the association between p53 Arg72Pro polymorphism and cancer risk remains unclear, possibly due to the pro-tumor potential of p53 under metabolic stress. Here, we hypothesized that the p53 Arg72Pro polymorphism plays different roles during tumorigenesis by adiposity status. We measured baseline body mass index (BMI)...

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Identifiers

PMID: 36083231
DOI: 10.1111/cas.15572
PMCID: PMC9746027

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