Article
Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1-CXCR1/2-pathway.
Microvascular research - 1 Mar 2012
Svensjö Erik, Saraiva Elvira M, Amendola Rafael Silveira, Barja-Fidalgo Christina, Bozza Marcelo T, Lerner Ethan A, Teixeira Mauro M, Scharfstein Julio
Abstract excerpt
Experiments were designed to determine if the vasodilatory peptides maxadilan and pituitary adenylate cyclase-activating peptide (PACAP-38) may cause plasma leakage through activation of leukocytes and to what extent these effects could be due to PAC1 and CXCR1/2 receptor stimulation. Intravital microscopy of hamster cheek pouches utilizing FITC-dextran and rhodamine, respectively, as plasma and leukocyte markers...
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