NEGATIVE EFFECT OF ANTIBODIES AGAINST MAXADILAN ON THE FITNESS OF THE SAND FLY VECTOR OF AMERICAN VISCERAL LEISHMANIASIS

Abstract excerpt

Lutzomyia longipalpis expresses a salivary protein called maxadilan (MAX) that functions to dilate vertebrate blood vessels and thereby to facilitate the sand fly's acquisition of blood. We hypothesized that antibodies specific for one of many MAX variants would inhibit vasodilatory function of that variant. In vitro and in vivo experiments showed that antibodies against a specific MAX variant decreased...

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