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Integrated molecular characterization of chondrosarcoma reveals critical determinants of disease progression

11 Oct 2019

Abstract excerpt

Chondrosarcomas are primary cancers of cartilaginous tissue with highly contrasting prognoses. These tumors are defined by recurrent mutations in the IDH genes and other genetic alterations including inactivation of CDKN2A and COL2A1; however, these have no clinical value. Here we use multi-omics molecular profiles from a series of cartilage tumors and find an mRNA classification that identifies two subtypes of...

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PMID: 31604924
DOI: 10.1038/s41467-019-12525-7

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