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Article

Mutational mapping of pUL131A of human cytomegalovirus emphasizes its central role for endothelial cell tropism.

Journal of virology - 1 Jan 2012

Schuessler Andrea, Sampaio Kerstin Laib, Straschewski Sarah, Sinzger Christian

Abstract excerpt

The UL131A protein is part of a pentameric variant of the gcIII complex in the virion envelope of human cytomegalovirus (HCMV), which has been found essential for efficient entry into endothelial cells (ECs). Using a systematic mutational scanning approach, we aimed to define peptide motifs within the UL131A protein that contribute to EC infection. Mutant viruses were generated in which charged amino acids within...

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Identifiers

PMID: 22031943
DOI: 10.1128/JVI.05354-11
PMCID: PMC3255870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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