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Article

Protein pUL128 of Human Cytomegalovirus Is Necessary for Monocyte Infection and Blocking of Migration

4 Mar 2011

Abstract excerpt

We have previously shown that only endotheliotropic strains of human cytomegalovirus (HCMV), such as TB40E, infect monocytes and impair their chemokine-driven migration. The proteins encoded by the UL128-131A region (UL128, UL130, and UL131A) of the HCMV genome, which assemble into a pentameric gH-gL-UL128-UL130-UL131A envelope complex, have been recognized as determinants for HCMV endothelial cell tropism. The...

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PMID: 21367908
DOI: 10.1128/jvi.02100-10

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