Article
A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance.
Nature - 20 Nov 2003
Mah Thien-Fah, Pitts Betsey, Pellock Brett, Walker Graham C, Stewart Philip S, O'Toole George A
Abstract excerpt
Biofilms are surface-attached microbial communities with characteristic architecture and phenotypic and biochemical properties distinct from their free-swimming, planktonic counterparts. One of the best-known of these biofilm-specific properties is the development of antibiotic resistance that can be up to 1,000-fold greater than planktonic cells. We report a genetic determinant of this high-level resistance in...
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