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Article

Stabilization of the α2 isoform of Na,K-ATPase by mutations in a phospholipid binding pocket.

The Journal of biological chemistry - 16 Dec 2011

Kapri-Pardes Einat, Katz Adriana, Haviv Haim, Mahmmoud Yasser, Ilan Micha, Khalfin-Penigel Irena, Carmeli Shmuel, Yarden Oded, Karlish Steven J D

Abstract excerpt

The α2 isoform of Na,K-ATPase plays a crucial role in Ca(2+) handling, muscle contraction, and inotropic effects of cardiac glycosides. Thus, structural, functional, and pharmacological comparisons of α1, α2, and α3 are of great interest. In Pichia pastoris membranes expressing human α1β1, α2β1, and α3β1 isoforms, or using the purified isoform proteins, α2 is most easily inactivated by heating and detergent (α2 ≫...

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PMID: 22027833
DOI: 10.1074/jbc.M111.293852
PMCID: PMC3234826

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FXYD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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