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Article

Multiple-peptidase mutants of Lactococcus lactis are severely impaired in their ability to grow in milk.

Journal of bacteriology - 1 May 1996

Mierau I, Kunji E R, Leenhouts K J, Hellendoorn M A, Haandrikman A J, Poolman B, Konings W N, Venema G, Kok J

Abstract excerpt

To examine the contribution of peptidases to the growth of lactococcus lactis in milk, 16 single- and multiple-deletion mutants were constructed. In successive rounds of chromosomal gene replacement mutagenesis, up to all five of the following peptidase genes were inactivated (fivefold mutant): pepX, pepO, pepT, pepC, and pepN. Multiple mutations led to slower growth rates in milk, the general trend being that...

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Identifiers

PMID: 8631666
DOI: 10.1128/jb.178.10.2794-2803.1996
PMCID: PMC178013

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Multiple-peptidase mutants of Lactococcus lactis are severely impaired in their ability to grow in milk.PMID 8631666Read ↗

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Genetic characterization of pepP, which encodes an aminopeptidase P whose deficiency does not affect Lactococcus lactis growth in milk, unlike deficiency of the X-prolyl dipeptidyl aminopeptidase.Semantic proximity Read ↗

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