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Article

Cepharanthine exhibits a potent anticancer activity in p53-mutated colorectal cancer cells through upregulation of p21Waf1/Cip1.

Oncology reports - 1 Jan 2018

Rattanawong Arkornnut, Payon Vilawan, Limpanasittikul Wacharee, Boonkrai Chatikorn, Mutirangura Apiwat, Wonganan Piyanuch

Abstract excerpt

Cepharanthine (CEP), a biscoclurine alkaloid isolated from Stephania cepharantha Hayata, has demonstrated anticancer activity in several different types of cancer cells. Colorectal cancer (CRC) is one of the most common cancers in both men and women. Mutated p53 in CRC was reported to be associated with resistance to commonly used chemotherapeutic agents including, 5‑fluorouracil, oxaliplatin and irinotecan. Many...

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Identifiers

PMID: 29138869
DOI: 10.3892/or.2017.6084

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