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Article

MHC class I-specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice.

The Journal of experimental medicine - 21 Nov 2011

Strait Richard T, Hicks Wyenona, Barasa Nathaniel, Mahler Ashley, Khodoun Marat, Köhl Jörg, Stringer Keith, Witte David, Van Rooijen Nico, Susskind Brian M, Finkelman Fred D

Abstract excerpt

Transfusion-related acute lung injury (TRALI), a form of noncardiogenic pulmonary edema that develops during or within 6 h after a blood transfusion, is the most frequent cause of transfusion-associated death in the United States. Because development of TRALI is associated with donor antibodies (Abs) reactive with recipient major histocompatibility complex (MHC), a mouse model has been studied in which TRALI-like...

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Identifiers

PMID: 22025304
DOI: 10.1084/jem.20110159
PMCID: PMC3256958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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