Article
Genotypic analyses of Richter's syndrome.
Cancer - 15 Feb 1991
Bernard D J, Bignon Y J, Pauchard J, Ramos F, Fonck Y, Courjal F, Chollet P, Plagne R
Abstract excerpt
The authors report the immunogenotype of two cases of Richter's syndrome. The immunoglobulin gene rearrangement pattern obtained on Southern Blot analysis was found in both cases to be the same in leukemic blood cells and in the tissue involved by the lymphoma. The beta chain and gamma chain T-cell receptor gene rearrangement pattern exhibited a germ-line configuration in the peripheral blood cells and in the...
Topics
- Aged
- Blotting, Southern
- Clone Cells
- DNA, Neoplasm
- Genotype
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
- Lymphoma, Large B-Cell, Diffuse
- Male
- Nucleic Acid Hybridization
- Syndrome