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Article

Rescue of HIV-1 long-time archived X4 strains to escape maraviroc.

Antiviral research - 1 Dec 2011

Baatz Franky, Struck Daniel, Lemaire Morgane, De Landtsheer Sebastien, Servais Jean-Yves, Arendt Vic, Schmit Jean-Claude, Perez Bercoff Danielle

Abstract excerpt

Entry of Human Immunodeficiency Virus type 1 (HIV-1) into target cells is mediated by the CD4 receptor and a coreceptor, CCR5 or CXCR4. Maraviroc interferes with HIV entry by binding the CCR5 coreceptor. Virological failure to maraviroc-containing regimens can occur through the emergence of resistance, or through tropism evolution and broadened coreceptor usage. In the latter case, the physiological relevance of...

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Identifiers

PMID: 22020304
DOI: 10.1016/j.antiviral.2011.10.003

Genes

CCR5
CXCR4

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