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Evaluation of two approaches to genotyping major histocompatibility complex class I in a passerine-CE-SSCP and 454 pyrosequencing.

Molecular ecology resources - 1 Mar 2012

Promerová Marta, Babik Wiesław, Bryja Josef, Albrecht Tomáš, Stuglik Michał, Radwan Jacek

Abstract excerpt

Genes of the highly dynamic major histocompatibility complex (MHC) are directly linked to individual fitness and are of high interest in evolutionary ecology and conservation genetics. Gene duplication and positive selection usually lead to high levels of polymorphism in the MHC region, making genotyping of MHC a challenging task. Here, we compare the performance of two methods for MHC class I genotyping in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22018268
DOI: 10.1111/j.1755-0998.2011.03082.x

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