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Article

Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer.

Genome biology - 19 Oct 2011

Kloosterman Wigard P, Hoogstraat Marlous, Paling Oscar, Tavakoli-Yaraki Masoumeh, Renkens Ivo, Vermaat Joost S, van Roosmalen Markus J, van Lieshout Stef, Nijman Isaac J, Roessingh Wijnand, van 't Slot Ruben, van de Belt José, Guryev Victor, Koudijs Marco, Voest Emile, Cuppen Edwin

Abstract excerpt

BACKGROUND: Structural rearrangements form a major class of somatic variation in cancer genomes. Local chromosome shattering, termed chromothripsis, is a mechanism proposed to be the cause of clustered chromosomal rearrangements and was recently described to occur in a small percentage of tumors. The significance of these clusters for tumor development or metastatic spread is largely unclear. RESULTS: We used...

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Source

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Identifiers

PMID: 22014273
DOI: 10.1186/gb-2011-12-10-r103
PMCID: PMC3333773

Genes

APC
EXO1
KRAS
NOTCH2
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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