Article
Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer.
Genome biology - 19 Oct 2011
Kloosterman Wigard P, Hoogstraat Marlous, Paling Oscar, Tavakoli-Yaraki Masoumeh, Renkens Ivo, Vermaat Joost S, van Roosmalen Markus J, van Lieshout Stef, Nijman Isaac J, Roessingh Wijnand, van 't Slot Ruben, van de Belt José, Guryev Victor, Koudijs Marco, Voest Emile, Cuppen Edwin
Abstract excerpt
BACKGROUND: Structural rearrangements form a major class of somatic variation in cancer genomes. Local chromosome shattering, termed chromothripsis, is a mechanism proposed to be the cause of clustered chromosomal rearrangements and was recently described to occur in a small percentage of tumors. The significance of these clusters for tumor development or metastatic spread is largely unclear. RESULTS: We used...
Topics
- Case-Control Studies
- Chromosome Aberrations
- Chromosomes, Human
- Colorectal Neoplasms
- Computational Biology
- DNA Repair Enzymes
- DNA, Neoplasm
- DNA-Binding Proteins
- Exodeoxyribonucleases