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Article

Overexpression of hepatoma-derived growth factor in melanocytes does not lead to oncogenic transformation.

BMC cancer - 20 Oct 2011

Sedlmaier Angela, Wernert Nicolas, Gallitzendörfer Rainer, Abouzied Mekky M, Gieselmann Volkmar, Franken Sebastian

Abstract excerpt

BACKGROUND: HDGF is a growth factor which is overexpressed in a wide range of tumors. Importantly, expression levels were identified as a prognostic marker in some types of cancer such as melanoma. METHODS: To investigate the presumed oncogenic/transforming capacity of HDGF, we generated transgenic mice overexpressing HDGF in melanocytes. These mice were bred with mice heterozygous for a defective copy of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22014102
DOI: 10.1186/1471-2407-11-457
PMCID: PMC3213223

Genes

HDGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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