Article
A rare variant at the KYNU gene is associated with kynureninase activity and essential hypertension in the Han Chinese population.
Circulation. Cardiovascular genetics - 1 Dec 2011
Zhang Yi, Shen Jie, He Xin, Zhang Kuixing, Wu Shengnan, Xiao Bing, Zhou Xueya, Phillips Robert S, Gao Pingjin, Jeunemaitre Xavier, Zhu Dingliang
Abstract excerpt
BACKGROUND: Genetic studies in mouse and human suggest that kynureninase activity may influence blood pressure and renal function. The gene coding kynureninase (KYNU) is also located on chromosome band 2q14-q23, where a linkage peak for essential hypertension was previously detected in the Chinese Han population. METHODS AND RESULTS: After having found no association with common polymorphisms, this study aimed to...
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