Article
[A polymorphism of kynureninase gene in a hypertensive candidate chromosomal region is associated with essential hypertension].
Zhonghua xin xue guan bing za zhi - 1 Jul 2005
Zhang Yi, Zhang Kui-xing, He Xin, Yuan Wen-tao, Wang Gu-liang, Mao Shou-yu, Gao Ping-jin, Huang Wei, Zhu Ding-liang
Abstract excerpt
OBJECTIVE: To identify single nucleotide polymorphisms (SNP) in the regulatory and coding regions of human kynureninase (KYNU) gene in a hypertensive candidate chromosomal region 2q14-q23 of Han Chinese, and to investigate the relationship between polymorphisms in KYNU and essential hypertension. METHODS: The SNPs in the promoter region and exons of the KYNU gene were detected by direct DNA sequencing. Genotyping...
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