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CMAX3: A Robust Statistical Test for Genetic Association Accounting for Covariates.

Genes - 28 Oct 2021

Chen Zhongxue, Zang Yong

Abstract excerpt

The additive genetic model as implemented in logistic regression has been widely used in genome-wide association studies (GWASs) for binary outcomes. Unfortunately, for many complex diseases, the underlying genetic models are generally unknown and a mis-specification of the genetic model can result in a substantial loss of power. To address this issue, the MAX3 test (the maximum of three separate test statistics)...

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PMID: 34828328
DOI: 10.3390/genes12111723
PMCID: PMC8622598

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