Article
Robust association tests under different genetic models, allowing for binary or quantitative traits and covariates.
Behavior genetics - 1 Sept 2011
So Hon-Cheong, Sham Pak C
Abstract excerpt
The association of genetic variants with outcomes is usually assessed under an additive model, for example by the trend test. However, misspecification of the genetic model will lead to a reduction in power. More robust tests for association might therefore be preferred. A useful approach is to consider the maximum of the three test statistics under additive, dominant and recessive models (MAX3). The p-value...
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