Article
Severe factor X deficiency in three unrelated Palestinian patients is caused by homozygosity for the mutation c302delG-correlation with thrombin generation and thromboelastometry.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Dec 2011
Livnat Tami, Shenkman Boris, Kenet Gili, Tamarin Ilia, Gillis Samuel, Varon David, Iijima Kenji, Zivelin Ariella, Salomon Ophira
Abstract excerpt
Factor X (FX) is one of the vitamin K-dependent serine proteases, which forms the prothrombinase complex converting prothrombin into thrombin. To search for mutations in F10 gene giving rise to severe FX deficiency and to study the contribution of thrombin generation and thromboelastometry as a tool for evaluation of hemostasis. Mutations in the F10 gene were sought by direct sequencing of all the eight exons and...
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