Article
Beta-thalassemia in Yugoslavia.
Hemoglobin - 1 Jan 1990
Dimovski A, Efremov D G, Jankovic L, Juricic D, Zisovski N, Stojanovski N, Nikolov N, Petkov G T, Reese A L, Stoming T A
Abstract excerpt
This study concerned the evaluation of beta-thalassemia alleles in nearly 50 patients with beta-thalassemia major and in 130 -thalassemia heterozygotes using gene amplification and dot-blot hybridization with synthetic probes. Fourteen different mutations were observed; of these, three (IVS-I-110; IVS-I-6; IVS-I-1) account for some 75% of all beta-thalassemia alleles. Newly discovered variants, i.e. T----C in the...
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