Article
Rapid detection of beta-Thalassemia alleles in Egypt using naturally or amplified created restriction sites and direct sequencing: a step in disease control.
Hemoglobin - 1 Jan 2007
Hussein Gehan, Fawzy Manal, Serafi Taher El, Ismail Emad F, Metwally Dina El, Saber Mohamed A, Giansily Muriel, Schved Jean-François, Pissard Serge, Martinez Patricia Aguilar
Abstract excerpt
beta-Thalassemia (thal), the most common genetic disorder in Egypt, is a major health problem with an estimated carrier rate of 9-10%. This study, aimed at describing the beta-globin gene mutations in the Suez Canal area, an important Egyptian region, to provide a foundation for a disease control program. We studied 44 beta-thalassemic patients (and their relatives) from 35 families living in this region. The...
Topics
- Adolescent
- Adult
- Amino Acid Sequence
- Base Sequence
- Child
- Child, Preschool
- Consanguinity
- DNA Fingerprinting
- DNA Mutational Analysis
- Egypt