Article
Beta-thalassemia in Turkey.
Hemoglobin - 1 Jan 1990
Oner R, Altay C, Gurgey A, Aksoy M, Kilinç Y, Stoming T A, Reese A L, Kutlar A, Kutlar F, Huisman T H
Abstract excerpt
A review is presented of the various beta-thalassemia alleles observed in nearly 191 patients with beta-thalassemia major and their 182 heterozygous relatives. Determination was by gene amplification and dot-blot hybridization with synthetic probes, specific for 27 different mutations. Eighteen mutations have been observed; six of these account for nearly 83% of all thalassemia abnormalities. A new mutation, i.e....
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