Article
Spectrum of beta-thalassemia in Jordan: identification of two novel mutations.
American journal of hematology - 1 Sept 2001
Sadiq M F, Eigel A, Horst J
Abstract excerpt
Two hundred and forty-four beta-thalassemia alleles were identified from 135 unrelated occasionally and periodically transfusion dependent beta- and S/beta-thalassemia patients from all regions of Jordan. Allele identification was achieved by PCR amplification of beta-globin genes, dot-blotting the amplified DNA, hybridization with allele specific synthetic probes, and direct sequencing of amplified genomic DNA....
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