Article
Spectrum of beta-thalassemia in Jordan: identification of two novel mutations.
American journal of hematology - 1 Sept 2001
Sadiq M F, Eigel A, Horst J
Abstract excerpt
Two hundred and forty-four beta-thalassemia alleles were identified from 135 unrelated occasionally and periodically transfusion dependent beta- and S/beta-thalassemia patients from all regions of Jordan. Allele identification was achieved by PCR amplification of beta-globin genes, dot-blotting the amplified DNA, hybridization with allele specific synthetic probes, and direct sequencing of amplified genomic DNA....
Topics
- Alleles
- DNA Mutational Analysis
- Globins
- Humans
- Jordan
- Mutation
- beta-Thalassemia