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An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters

14 Aug 2019

Abstract excerpt

Anaerobic bacteria represent an overlooked rich source of biological and chemical diversity. Due to the challenge of cultivation and genetic intractability, assessing the capability of their biosynthetic gene clusters (BGCs) for secondary metabolite production requires an efficient heterologous expression system. However, this kind of host system is still unavailable. Here, we use the facultative anaerobe...

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PMID: 31413323
DOI: 10.1038/s41467-019-11673-0

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