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Article

Deciphering the role of RND efflux transporters in Burkholderia cenocepacia.

PloS one - 19 Apr 2011

Bazzini Silvia, Udine Claudia, Sass Andrea, Pasca Maria Rosalia, Longo Francesca, Emiliani Giovanni, Fondi Marco, Perrin Elena, Decorosi Francesca, Viti Carlo, Giovannetti Luciana, Leoni Livia, Fani Renato, Riccardi Giovanna, Mahenthiralingam Eshwar, Buroni Silvia

Abstract excerpt

Burkholderia cenocepacia J2315 is representative of a highly problematic group of cystic fibrosis (CF) pathogens. Eradication of B. cenocepacia is very difficult with the antimicrobial therapy being ineffective due to its high resistance to clinically relevant antimicrobial agents and disinfectants. RND (Resistance-Nodulation-Cell Division) efflux pumps are known to be among the mediators of multidrug resistance...

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Identifiers

PMID: 21526150
DOI: 10.1371/journal.pone.0018902
PMCID: PMC3079749

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