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Article

rhBMP‐2 has adverse effects on human oral carcinoma cell lines in vivo

13 Oct 2011

Abstract excerpt

OBJECTIVES/HYPOTHESIS: To establish the relevance of the bone morphogenetic protein (BMP) signaling pathway in human oral squamous cell carcinoma (OSCCA) cell lines and determine if there is a biologic impact of stimulating this pathway with recombinant human (rh) BMP-2. STUDY DESIGN: In vitro laboratory investigations and in vivo analysis using an orthotopic animal model for oral cancer. METHODS: Gene expression...

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PMID: 21997819
DOI: 10.1002/lary.22345

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