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Article

Gene Therapy-Directed Osteogenesis: BMP-7-Transduced Human Fibroblasts Form Bone <i>in Vivo</i>

20 May 2000

Abstract excerpt

An ex vivo gene therapy strategy was used to achieve localized skeletal regeneration in vivo. When an adenovirus vector engineered to express bone morphogenetic protein 7 transduced human gingival fibroblasts or rat dermal fibroblasts, these nonosteogenic tissues formed bone and supported the development of hematopoietic tissue when transplanted into immunocompromised mice. Transduced gingival fibroblasts formed...

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PMID: 10834621
DOI: 10.1089/10430340050015248

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