Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell line

1 Mar 2011

Abstract excerpt

Previously, based on high ALDH activity, we showed that cancer stem cells (CSCs) could be identified as ALDH(br) cells from an aggressive human osteosarcoma OS99-1 cell line. In this study, we evaluate the impact of BMP-2 on CSCs.Three types of BMP receptors were expressed in freshly sorted ALDH(br) cells. In vitro, growth of the sorted ALDH(br) cells was inhibited by BMP-2. Using RT-PCR analysis, BMP-2 was found...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Hedgehog Signaling Pathway Studies
Share to Mesenchymal stem cell research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21178508
DOI: 10.4161/cbt.11.5.14372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell linePMID 21178508Read ↗

Bone formation induced by BMP-2 in human osteosarcoma cellsSemantic proximity Read ↗

Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99‐1 cells based on high aldehyde dehydrogenase activitySemantic proximity Read ↗

BMP signaling in cancer stemness and differentiationSemantic proximity Read ↗

Global Gene Expression Analysis of Canine Osteosarcoma Stem Cells Reveals a Novel Role for COX-2 in Tumour InitiationSemantic proximity Read ↗

Human primary bone sarcomas contain CD133 <sup>+</sup> cancer stem cells displaying high tumorigenicity <i>in vivo</i>Semantic proximity Read ↗

Osteosarcoma Stem Cells Have Active Wnt/β‐catenin and Overexpress SOX2 and KLF4Semantic proximity Read ↗

Identification of Stem Cell Related Gene Expression From the Osteosarcoma Cell Core SideSemantic proximity Read ↗

Identifying an ovarian cancer cell hierarchy regulated by bone morphogenetic protein 2Semantic proximity Read ↗

Seven BMPs and all their receptors are simultaneously expressed in osteosarcoma cellsSemantic proximity Read ↗

Characterization of stem cell attributes in human osteosarcoma cell linesSemantic proximity Read ↗

Runx2 expression: A mesenchymal stem marker for cancerSemantic proximity Read ↗

Acquisition of cancer stem cell properties in osteosarcoma cells by defined factorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.