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Article

Darwinian evolution of prions in cell culture.

Science (New York, N.Y.) - 12 Feb 2010

Li Jiali, Browning Shawn, Mahal Sukhvir P, Oelschlegel Anja M, Weissmann Charles

Abstract excerpt

Prions are infectious proteins consisting mainly of PrP(Sc), a beta sheet-rich conformer of the normal host protein PrP(C), and occur in different strains. Strain identity is thought to be encoded by PrP(Sc) conformation. We found that biologically cloned prion populations gradually became hetero...

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Identifiers

PMID: 20044542
DOI: 10.1126/science.1183218
PMCID: PMC2848070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20044542-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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