Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes.

Archives of toxicology - 1 May 2016

Jetten Marlon J A, Ruiz-Aracama Ainhoa, Coonen Maarten L J, Claessen Sandra M, van Herwijnen Marcel H M, Lommen Arjen, van Delft Joost H M, Peijnenburg Ad A C M, Kleinjans Jos C S

Abstract excerpt

Acetaminophen (APAP) is a readily available over-the-counter drug and is one of the most commonly used analgesics/antipyretics worldwide. Large interindividual variation in susceptibility toward APAP-induced liver failure has been reported. However, the exact underlying factors causing this variability in susceptibility are still largely unknown. The aim of this study was to better understand this variability in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetaminophen
Share to Analgesics, Non-Narcotic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemical and Drug Induced Liver Injury

Share to Dose-Response Relationship, Drug

Share to Gene Regulatory Networks

Share to Hepatocytes

Share to Metabolomics

Share to Primary Cell Culture

Source

Open in PubMed Open full text

Identifiers

PMID: 26104854
DOI: 10.1007/s00204-015-1545-2
PMCID: PMC4830893

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes.PMID 26104854Read ↗

Predose and Postdose Blood Gene Expression Profiles Identify the Individuals Susceptible to Acetaminophen-Induced Liver Injury in Rats.Semantic proximity Read ↗

Metabolic phenotyping applied to pre-clinical and clinical studies of acetaminophen metabolism and hepatotoxicity.Semantic proximity Read ↗

The Genomics of Elevated ALT and Adducts in Therapeutic Acetaminophen Treatment: a Pilot Study.Semantic proximity Read ↗

Toxicogenomics-based prediction of acetaminophen-induced liver injury using human hepatic cell systemsSemantic proximity Read ↗

Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure.Semantic proximity Read ↗

Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses.Semantic proximity Read ↗

Knockdown of Long Noncoding RNAs Hepatocyte Nuclear Factor 1α Antisense RNA 1 and Hepatocyte Nuclear Factor 4α Antisense RNA 1 Alters Susceptibility of Acetaminophen-Induced Cytotoxicity in HepaRG Cells.Semantic proximity Read ↗

Comparative analysis of gene expression between mice and humans in acetaminophen-induced liver injury by integrating bioinformatics analysisSemantic proximity Read ↗

Deciphering Acetaminophen-Induced Hepatotoxicity: The Crucial Role of Transcription Factors like Nuclear Factor Erythroid 2-Related Factor 2 as Genetic Determinants of Susceptibility to Drug-Induced Liver Injury.Semantic proximity Read ↗

Genetic Association of Single Nucleotide Polymorphisms with Acetaminophen-Induced Hepatotoxicity.Semantic proximity Read ↗

Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice.Semantic proximity Read ↗

Interindividual variability in gene expression profiles in human hepatocytes and comparison with HepaRG cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.