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Article

Kunjin virus replicon-based vaccines expressing Ebola virus glycoprotein GP protect the guinea pig against lethal Ebola virus infection.

The Journal of infectious diseases - 1 Nov 2011

Reynard O, Mokhonov V, Mokhonova E, Leung J, Page A, Mateo M, Pyankova O, Georges-Courbot M C, Raoul H, Khromykh A A, Volchkov V E

Abstract excerpt

Pre- or postexposure treatments against the filoviral hemorrhagic fevers are currently not available for human use. We evaluated, in a guinea pig model, the immunogenic potential of Kunjin virus (KUN)-derived replicons as a vaccine candidate against Ebola virus (EBOV). Virus like particles (VLPs) containing KUN replicons expressing EBOV wild-type glycoprotein GP, membrane anchor-truncated GP (GP/Ctr), and mutated...

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Share to Dose-Response Relationship, Immunologic
Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycoproteins

Share to Guinea Pigs

Share to Hemorrhagic Fever, Ebola

Share to Vaccines, Attenuated

Share to Vaccines, Synthetic

Share to West Nile virus

Source

Open in PubMed Open full text

Identifiers

PMID: 21987742
DOI: 10.1093/infdis/jir347
PMCID: PMC3189994

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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