Article
Cellular and molecular mechanisms of immune dysregulation and autoimmunity.
Cellular immunology - 1 Dec 2016
Azizi Gholamreza, Pouyani Mohsen Rastegar, Abolhassani Hassan, Sharifi Laleh, Dizaji Majid Zaki, Mohammadi Javad, Mirshafiey Abbas, Aghamohammadi Asghar
Abstract excerpt
Primary immunodeficiencies (PIDs) constitute a large group of rare disorders that affect the function of the immune system. A specific group of PIDs entitled "diseases of immune dysregulation" are developed due to mutation in the genes which have critical roles in the regulation of immune responses and immunological tolerance. This group of PID patients develop autoimmune and inflammatory disorders as a result of...
Topics
- Animals
- Autoimmunity
- Humans
- Immune Tolerance
- Immunologic Deficiency Syndromes
- Mutation
- T-Lymphocytes, Regulatory